pi3 kinase การใช้

PI3 kinase inhibitors have been of interest, but they tend to be highly toxic and cause diarrhea.
With an IC 50 of 1.4 礛 it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor.
The leading PI3 kinase drug discovered in their collaboration with Piramed was licensed to Genentech as GDC-0941 ( pictilsib ) and is undergoing Phase II clinical trials.
Activation of Ras has the potential to initiate three signaling pathways downstream of Ras : Ras?! Raf?! MAP kinase pathway, PI3 kinase pathway, and Ral pathway.
In particular, the researchers found that one enzyme, known as age-1 / PI3 kinase, needs to be present in order for this muscle deterioration to occur.